University at Buffalo
The State University of  New York
CCR
Center for Computational Research
Number of Atoms in Structure
0              100           1,000        10,000       100,000
Conventional Direct Methods
Shake-and-Bake
Multiple Isomorphous Replacement
Se-Met
Se-Met with Shake-and-Bake
Vancomycin
190kDa
?
?
Phasing and Structure Size