University at Buffalo
The State University of New York
CCR
Center for
Computational Research
Physiology
Cellular biology
Biochemistry
Neurobiology
Endocrinology
etc.
Biomedical
Data:
High Complexity and Large Scale
High Complexity and Large Scale
Courtesy
of
Rick
Stevens
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billions
DNA sequences
alignments
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYT...
Proteins
sequence
2º structure
3º structure
Hundred
thousands
thousands
Protein-Protein
Interactions
metabolism
pathways
receptor-ligand
4º structure
millions
billions
millions
millions
ESTs
Expression patterns
Large-scale screens
Genetics and Maps
Linkage
Cytogenetic
Clone-based
Polymorphism
and Variants
genetic variants
individual patients
epidemiology