| Phasing and Structure Size |
| Se-Met with
Shake-and-Bake |
| ? |
| Se-Met |
| 190kDa |
| Multiple
Isomorphous Replacement |
| ? |
| Shake-and-Bake |
| Conventional
Direct Methods |
| Vancomycin |
| 0 100 1,000 10,000
100,000 |
| Number
of Atoms in Structure |