n Biomedical Informatics Research Network [BIRN] q Evolving reference set of brains q Essential data for developing therapies for neurological disorders (Multiple Sclerosis, Alzheimer’s) n Pre-TeraGrid: q One PET or MRI lab q Small patient base q 4 TB collection n Post-TeraGrid q Many collaborating labs q Larger population sample q 400 TB data collection m More brains, higher resolution q Multiple scale data integration and analysis