University at Buffalo
The State University of  New York
CCR
Center for Computational Research
Recent Biomedical Advances
(Buffalo, NY)
nPSA Test (screen for Prostate Cancer)
nAvonex: Interferon Treatment for Multiple Sclerosis
nArtificial Blood
nNicorette Gum
nFetal Viability Test
nEdible Vaccine for Hepatitis C
nTimed-Release Insulin Therapy
nAnti-Arrythmia Therapy
qTarantula venom
nDirect Methods Structure Determination
qListed on “Top Ten Algorithms of the 20th Century”
nVancomycin
nGramacidin A
nHigh Throughput  Crystallization Method: Patented
nNIH National Genomics Center: Northeast Consortium
nHoward Hughes Medical Institute: Center for Genomics & Proteomics
n
•PSA (Prostate Specific Antigen) Test for early detection of Prostate Cancer – IP owned by RPCI – receive royalties
•Avonex – most widely prescribed drug for relapsing MS – first treatment shown to slow progress of the disease – approved in 1996 - developed by Larry Jacobs group – sold by Biogen ($0.5B per year) – WNY/UB doesn’t receive any direct funds from the sale of Avonex
•Nicorette Gum – Developed by professor doing decompression studies on sailors who needed to keep taking a break to smoke a cigarette, so developed this to enable him to finish his decompression studies – do we make anything??
•Artificial Blood –
•Tarantula Venom – prevent atrial fibrillation, which is a leading cause of death following a heart attack – so far, works for rabbits (Fred Sachs)
•Developed and patented a high-throughput search process for structural biology that tests 1536 “chemical cocktails” to enhance method of crystallization.
•Edible Vaccine for Hepatitis C